Earth’s natural resources and environments are being deteriorated at unprecedented rates. One of the most viable option of solving this major problem is for humans to become a space faring civilization. However, Humans have their physiology developed to live on Earth; lack of gravity in space can affect said physiology and human mental health. Biotechnology including food, medicine, energy, and more are playing significant role in space colonization. This class explores the future of biotechnology in space through series of lectures, workshops, and projects related to space exploration.